Pseudomonas - Candida Interactions: An Ecological Role for Virulence Factors

作者：Deborah A. Hogan, Roberto Kolter · 发表于：Science · 年份：2002 · DOI：10.1126/science.1070784 · 被引用次数：583 · 研究领域：Antifungal resistance and susceptibility、Bacterial biofilms and quorum sensing、Antibiotic Resistance in Bacteria

Bacterial-fungal interactions have great environmental, medical, and economic importance, yet few have been well characterized at the molecular level. Here, we describe a pathogenic interaction between Pseudomonas aeruginosa and Candida albicans, two opportunistic pathogens. P. aeruginosa forms a dense biofilm on C. albicans filaments and kills the fungus. In contrast, P. aeruginosa neither binds to nor kills yeast-form C. albicans. Several P. aeruginosa virulence factors that are important in disease are involved in the killing of C. albicans filaments. We propose that many virulence factors studied in the context of human infection may also have a role in bacterial-fungal interactions.