Effect of Intravenous Infusions of Ethanol upon Estimated Hepatic Blood Flow in Man1

作者：Albert I. Mendeloff · 发表于：Journal of Clinical Investigation · 年份：1954 · 被引用次数：91 · 研究领域：Anesthesia and Sedative Agents、Poisoning and overdose treatments、Renal function and acid-base balance

During the course of studies concerning the utilization by the human liver of parenteral feeding solutions containing ethanol, it was observed that these infusions resulted consistently in changes in the estimated hepatic blood flow. The amount of ethanol infused into these human subjects produced blood ethanol concentrations far below those known to be intoxicating ( 1 ), and lower than those levels reported to achieve some degree of postoperative sedation (2). Since even massive ethanol dosage is reportedly without effect on mammalian hemodynamics (3), it seemed unlikely that the changes in estimated hepatic blood flow observed here were due to gross changes in the circulation. This report demonstrates that the infusion of small amounts of ethanol in saline into unanesthetized adult human subjects produces consistently significant increases in estimated hepatic blood flow, most probably as a result of a specific decrease in splanchnic peripheral resistance.