Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

作者：Henry C. Baggett, Alan J. Parkinson, Pam T. Muth, Benjamin D. Gold, Bradford D. Gessner · 发表于：PEDIATRICS · 年份：2006 · DOI：10.1542/peds.2005-1129 · 被引用次数：124 · 研究领域：Helicobacter pylori-related gastroenterology studies、Iron Metabolism and Disorders、Nutrition, Genetics, and Disease

OBJECTIVES: Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska. METHODS: We enrolled 68% (688) of the 7- to 11-year-old children from 10 predominantly Alaska Native villages in southwestern Alaska. We collected venous blood samples to assess iron deficiency and anemia. Each child was tested for active H pylori infection by 13C-urea breath test (UBT). Evaluated risk factors included age, gender, village of residence, number of household members, number of household members who were younger than 5 years, recent antibiotic use, and household water source. RESULTS: Of 688 enrolled children, iron deficiency was present in 38%, iron-deficiency anemia was present in 7.8%, and H pylori infection by UBT was present in 86%. Iron deficiency was independently associated with living in a household with >6 people and village of residence. H pylori infection by UBT was independently associated with child's age > or =10 years and village of residence. Ninety-one percent of children with iron deficiency had H pylori infection by UBT, and children with active H pylori infection were more likely to be iron deficient than uninfected children. Children with H pylori infection by UBT were also more likely to have iron-deficiency anemia than uninfected children. CONCLUSIONS: In t...