A COMPARISON OF ADRENAL STEROID DIABETES AND PANCREATIC DIABETES IN THE RAT

作者：Dwight J. Ingle, R. H. Sheppard, JOHN S. EVANS, Marvin H. Kuizenga · 发表于：Endocrinology · 年份：1945 · DOI：10.1210/endo-37-5-341 · 被引用次数：75 · 研究领域：Diet and metabolism studies、Adipose Tissue and Metabolism、Hormonal Regulation and Hypertension

THE C-11-oxygenated adrenal cortical steriods have the property of stimulating gluconeogenesis from-protein (Long, Katzin and Fry, 1940) and probably of inhibiting the utilization of carbohydrate (Ingle and Thorn, 1941). How are these two effects related? Do they represent independent actions of the cortical hormones or is one effect primary to the other?Ingle (1942) and Drury (1942) have suggested that the inhibition of carbohydrate utilization may cause the increase in gluconeogenesis since an increase in protein catabolism also occurs during pancreatic diabetes, phlorhizin diabetes, starvation etc. If this hypothesis is correct it should be possible to modify the extent of nitrogen loss during adrenal steroid diabetes by treatment with insulin. The present study was intended to test the above hypothesis by comparing the effects of insulin on the nitrogen, electrolyte and carbohydrate balance of rats having pancreatic diabetes with the effects of insulin in similar animals having adrenal steroid diabetes induced according to Ingle (1941).