Association of the C677T Polymorphism in the MTHFR Gene with Hemorrhagic Stroke: A Meta-Analysis

作者：Shan Kang, Xinxin Zhao, Lingling Liu, Wenlong Wu, Dongfeng Zhang · 发表于：Genetic Testing and Molecular Biomarkers · 年份：2013 · DOI：10.1089/gtmb.2012.0295 · 被引用次数：31 · 研究领域：Folate and B Vitamins Research、Blood Coagulation and Thrombosis Mechanisms、Advanced MRI Techniques and Applications

AIMS: We performed a meta-analysis to assess the possible association between the MTHFR gene C677T polymorphism and hemorrhagic stroke. METHODS: A comprehensive search was conducted to identify all case-control or cohort design studies of the associations between C677T and HS. The fixed or random effect pooled measure was selected on the basis of a homogeneity test among studies. Heterogeneity among studies was evaluated using the I(2). Meta-regression and the "leave-one-out" sensitive analysis of Patsopoulos et al. were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using the Begg's test. RESULTS: Fifteen case-control studies corresponded to the inclusion criteria, including 2034 cases and 4485 controls for the present meta-analysis. After excluding articles that deviated from the Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between the MTHFR C677T genetic polymorphism and the risk of hemorrhagic stroke were observed in dominant (Odds ratio [OR] 1.611, 95% confidence interval [CI] 1.336-1.942), codominant (OR 1.500, 95% CI 1.330-1.692), and recessive (OR 1.695, 95% CI 1.409-2.038) models. CONCLUSIONS: The meta-analysis suggests that the MTHFR C667T genetic polymorphism was associated with increased risk of hemorrhagic stroke, and the T allele may be an important risk factor for hemorrhagic stroke. The findings are of importance to the genetic epidemio...