Bayesian Risk Mapping and Model-Based Estimation of Schistosoma haematobium–Schistosoma mansoni Co-distribution in Côte d′Ivoire

作者：Frédérique Chammartin, Clarisse A. Houngbedji, Eveline Hürlimann, Richard B. Yapi, Kigbafori Dieudonné Silué, Gotianwa Soro, Ferdinand N. Kouamé, Eliezer Kouakou N'Goran, Jürg Utzinger, Giovanna Raso, Penelope Vounatsou · 发表于：PLoS neglected tropical diseases · 年份：2014 · DOI：10.1371/journal.pntd.0003407 · 被引用次数：33 · 研究领域：Parasites and Host Interactions、Parasite Biology and Host Interactions、Zoonotic diseases and public health

BACKGROUND: Schistosoma haematobium and Schistosoma mansoni are blood flukes that cause urogenital and intestinal schistosomiasis, respectively. In Côte d'Ivoire, both species are endemic and control efforts are being scaled up. Accurate knowledge of the geographical distribution, including delineation of high-risk areas, is a central feature for spatial targeting of interventions. Thus far, model-based predictive risk mapping of schistosomiasis has relied on historical data of separate parasite species. METHODOLOGY: We analyzed data pertaining to Schistosoma infection among school-aged children obtained from a national, cross-sectional survey conducted between November 2011 and February 2012. More than 5,000 children in 92 schools across Côte d'Ivoire participated. Bayesian geostatistical multinomial models were developed to assess infection risk, including S. haematobium-S. mansoni co-infection. The predicted risk of schistosomiasis was utilized to estimate the number of children that need preventive chemotherapy with praziquantel according to World Health Organization guidelines. PRINCIPAL FINDINGS: We estimated that 8.9% of school-aged children in Côte d'Ivoire are affected by schistosomiasis; 5.3% with S. haematobium and 3.8% with S. mansoni. Approximately 2 million annualized praziquantel treatments would be required for preventive chemotherapy at health districts level. The distinct spatial patterns of S. haematobium and S. mansoni imply that co-infection is of little ...