Bioactive Saponins and Glycosides. XV. Saponin Constituents with Gastroprotective Effect from the Seeds of Tea Plant, Camellia sinensis L. var. assamica PIERRE, Cultivated in Sri Lanka. Structures of Assamsaponins A, B, C, D, and E.

作者：Toshiyuki Murakami, Junko Nakamura, Hisashi Matsuda, Masayuki Yoshikawa · 发表于：Chemical and Pharmaceutical Bulletin · 年份：1999 · DOI：10.1248/cpb.47.1759 · 被引用次数：77 · 研究领域：Natural product bioactivities and synthesis、Phytochemical Studies and Bioactivities、Phytochemicals and Antioxidant Activities

The saponin fraction from the seeds of the tea plant, Camellia sinensis L. var. assamica Pierre cultivated in Sri Lanka, was found to show a potent protective effect on gastric mucosal lesions induced by ethanol in rats. Nine new acylated polyhydroxyoleanene-type triterpene oligoglycosides called assamsaponins A-I were isolated from the active saponin fraction together with three known saponins, theasaponin E1 and E2 and camelliasaponin B1. The structures of assamsaponins A-E were elucidated on the basis of chemical and physicochemical evidence. Theasaponin E1 exhibited potent gastroprotective activity.