Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

作者：Robert L. Kirkman, Leslie V. Barrett, Glen N. Gaulton, V E Kelley, A. Ythier, Terry B. Strom · 发表于：The Journal of Experimental Medicine · 年份：1985 · DOI：10.1084/jem.162.1.358 · 被引用次数：193 · 研究领域：Immune Response and Inflammation、Viral Infections and Immunology Research、RNA Interference and Gene Delivery

Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.