CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

作者：Robert M. Umek, Alan D. Friedman, Steven Lanier McKnight · 发表于：Science · 年份：1991 · DOI：10.1126/science.1987644 · 被引用次数：724 · 研究领域：Ubiquitin and proteasome pathways、Signaling Pathways in Disease、Protein Degradation and Inhibitors

The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.