HLA class I genes integrated into murine cells are inducible by interferon

作者：Frédéric Rosa, Philippe P. Le Bouteiller, Annie Abadie, Zohair Mishal, François A. Lemonnier, Dominique Bourrel, Michel Lamotte, Jorge Kalil, Bertrand Jordan, Marc Mardoche Fellous · 发表于：European Journal of Immunology · 年份：1983 · DOI：10.1002/eji.1830130612 · 被引用次数：41 · 研究领域：Monoclonal and Polyclonal Antibodies Research、T-cell and B-cell Immunology、Immune Cell Function and Interaction

In human cells treated with interferon, there is an increase in the amount of HLA-A, B, C mRNA and, to a lower extent, membrane-bound antigen. However, the mechanism of this mRNA enhancement is still unknown. Using mouse L cells transfected with a unique class I HLA gene, we were able to show that both the related HLA mRNA and protein are increased after murine but not human interferon treatment. Moreover, the discrepancy between interferon-directed HLA mRNA and protein enhancement is also observed. The mouse transfected cells allowed us to study more precisely the origin of this discrepancy.