Identification of the ferroxidase centre in ferritin

作者：David M. Lawson, Amyra Treffry, Peter J. Artymiuk, Pauline M. Harrison, Stephen J. Yewdall, Alessandra Luzzago, Gianne Cesareni, Sonia Levi, Paolo Arosio · 发表于：FEBS Letters · 年份：1989 · DOI：10.1016/0014-5793(89)81040-3 · 被引用次数：313 · 研究领域：Iron Metabolism and Disorders、Trace Elements in Health、RNA regulation and disease

Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.