Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

作者：Deborah A. Carper, Chihiro Nishimura, Toshimichi Shinohara, Bernard Dietzchold, Graeme J. Wistow, Cheryl Mae Craft, Peter F. Kador, Jin H. Kinoshita · 发表于：FEBS Letters · 年份：1987 · DOI：10.1016/0014-5793(87)80905-5 · 被引用次数：172 · 研究领域：Aldose Reductase and Taurine、Biochemical effects in animals、Connexins and lens biology

Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH-dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40-50% homology with p-crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and p-crystallin are members of a superfamily of related proteins.