Lymphocytes: Circulation Altered by Trypsin

作者：Judith J. Woodruff, Bertram M. Gesner · 发表于：Science · 年份：1968 · DOI：10.1126/science.161.3837.176 · 被引用次数：130 · 研究领域：Immune Response and Inflammation、Barrier Structure and Function Studies

Rat thoracic duct lymphocytes altered by trypsin in vitro do not circulate normally. At early intervals after transfusion of lymphocytes labeled with chromium-51 selective accumulation of radioactivity in the lymph nodes is abolished, while uptake in the spleen is not reduced. Later, the cells appear to "home" to lymph nodes and recirculate to the lymph.