Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

作者：Aaron W. Grossman, Georgina M. Aldridge, Ivan Jeanne Weiler, William T. Greenough · 发表于：Journal of Neuroscience · 年份：2006 · DOI：10.1523/jneurosci.1790-06.2006 · 被引用次数：176 · 研究领域：Genetics and Neurodevelopmental Disorders、Ubiquitin and proteasome pathways、Epigenetics and DNA Methylation

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).