Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

作者：James P. Whitlock · 发表于：The Annual Review of Pharmacology and Toxicology · 年份：1990 · DOI：10.1146/annurev.pa.30.040190.001343 · 被引用次数：448 · 研究领域：Heme Oxygenase-1 and Carbon Monoxide

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More