Reexamination of Glucose-6-Phosphatase Activity in the Brain in Vivo: No Evidence for a Futile Cycle

作者：Thomas J. Nelson, Giovanni Lucignani, Steven A. Atlas, Alison M. Crane, Gerald A. Dienel, Louis Sokoloff · 发表于：Science · 年份：1985 · DOI：10.1126/science.2990038 · 被引用次数：83 · 研究领域：Glycogen Storage Diseases and Myoclonus、Mitochondrial Function and Pathology、Cancer, Hypoxia, and Metabolism

Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.