A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids

作者：Graham H. Goodwin, Clive Sanders, Ernest W. Johns · 发表于：European Journal of Biochemistry · 年份：1973 · DOI：10.1111/j.1432-1033.1973.tb03026.x · 被引用次数：793 · 研究领域：Peptidase Inhibition and Analysis、Cancer-related gene regulation、Ubiquitin and proteasome pathways

A new group of chromatin‐associated proteins having a high content of acidic and basic amino acids have been isolated from the 0.35 M NaCl‐extractable proteins from calf thymus. This new group, designated “high‐mobility group” proteins have been partially separated and some interesting new proteins identified. One such protein contains over 55% acidic and basic amino acids.