Carcinoma and adenomatous polyps of the colon and rectum in biopsy and organ tissue culture

作者：Milan Kalus · 发表于：Cancer · 年份：1972 · DOI：10.1002/1097-0142(197210)30:4<972::aid-cncr2820300418>3.0.co;2-a · 被引用次数：47 · 研究领域：Colorectal and Anal Carcinomas、Genetic factors in colorectal cancer、Colorectal Cancer Treatments and Studies

Carcinoma in situ was found in 16.0% of patients with histologically verified cases of solitary and multiple adenomatous polyps of the colon and rectum. In patients with adenomatous polyps only, the incidence was 6.1%. The incidence rose to 47.0% in the group of patients having adenomatous polyps associated with carcinoma in the same segment of the colon. This figure suggests that the diagnosis of carcinoma in situ in a polyp should be followed by careful search for frank adenocarcinoma in the proximity. Organ tissue cultures on the fibrin foam matrix demonstrated a morphological transition from cytologically benign adenomatous polyps into focal carcinoma in situ in more than two thirds of cultured cases. Moreover, a few of these polyps developed invasive features similar to those observed in cultures of colonic adenocarcinoma. The behavior of adenomatous polyps in tissue culture suggests a malignant potential of those lesions and their possible ability to become not only histologic, but also biologic cancers.