Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer

作者：Angela Santoni, Carlo Riccardi, Teresa Barlozzari, Ronald B. Herberman · 发表于：International Journal of Cancer · 年份：1980 · DOI：10.1002/ijc.2910260619 · 被引用次数：61 · 研究领域：Neuropeptides and Animal Physiology、Immune Cell Function and Interaction、Biopolymer Synthesis and Applications

Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.