Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

作者：Eva‐Maria Mandelkow, E.-M. Mandelkow, Gerard Drewes, Jacek Biernat, N. Gustke, Johan Van Lint, Jackie R. Vandenheede, Eva‐Maria Mandelkow, Eva‐Maria Mandelkow · 发表于：FEBS Letters · 年份：1992 · DOI：10.1016/0014-5793(92)81496-9 · 被引用次数：512 · 研究领域：Alzheimer's disease research and treatments、Microtubule and mitosis dynamics、Protein Structure and Dynamics

The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phosphorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments.