OSSEOUS DEVELOPMENT IN ENDOCRINE DISORDERS*

作者：Wm. Engelbach, A. Philip McMahon, ST. LOUIS · 发表于：Endocrinology · 年份：1924 · DOI：10.1210/endo-8-1-1 · 被引用次数：18 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Pituitary Gland Disorders and Treatments、Metabolism and Genetic Disorders

The striking variations of stature in the eunuch, the acromegalie, and the various types of infantilism have heen of historical interest even to the layman. An illustration of this interest is the prize offered by the philanthropist for the intermarriage of giants in order to produce a larger and stronger race. These outspoken differences in size and local osseous proportions of the individual were among the first signs giving impetus to the scientist to study the liormonic effects of the internal secretions upon skeleton growth. C. v. Langer (1872) was probably the first to distinguish between pathological and normal giants. To Pierre Marie (1888-89), Massalongo (1892), Sternberg (1895), Brissaud and Meige (1895), and Launois and Roy (1902-04) credit should be given for the earliest work relating the development of the osseous system in gigantism and acromegaly to the hypophysis. Tandler and Grosz (1907-10) in their studies of the skopzen directly associated the overgrowth of the long bones present in the early hypogonad states to castration.