Nitrosative and oxidative stress responses in fungal pathogenicity

作者：Alistair J. P. Brown, Ken Haynes, Janet Quinn · 发表于：Current Opinion in Microbiology · 年份：2009 · DOI：10.1016/j.mib.2009.06.007 · 被引用次数：173 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Plant-Microbe Interactions and Immunity

Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.