Patches and fences: probing for plasma membrane domains

作者：Michael A. Edidin · 发表于：Journal of Cell Science · 年份：1993 · DOI：10.1242/jcs.1993.supplement_17.24 · 被引用次数：63 · 研究领域：Lipid Membrane Structure and Behavior、Spectroscopy and Quantum Chemical Studies、Force Microscopy Techniques and Applications

Cell plasma membranes appear to be composed of domains, patches whose composition and function differ from the average for an entire membrane surface. Proteins and lipids may be segregated into domains by different mechanisms. Some of these mechanisms are discussed, followed by a summary of the evidence for membrane domains obtained in my laboratory. This evidence is largely based on measurements of the lateral diffusion of membrane proteins and lipids. Recent new approaches to the interpretation of lateral diffusion measurements, consideration of so-called fractal or long time-tails promise to give new insights into the stability and lifetime of membrane domains.