Murine ST2 gene is a member of the primary response gene family induced by growth factors

作者：Ken Yanagisawa, Toshihiko Tsukamoto, Toshimitsu Takagi, Shin‐ichi Tominaga · 发表于：FEBS Letters · 年份：1992 · DOI：10.1016/0014-5793(92)80282-l · 被引用次数：44 · 研究领域：IL-33, ST2, and ILC Pathways、Immune Cell Function and Interaction、T-cell and B-cell Immunology

The murine ST2 gene, which encodes a protein remarkably similar to the extracellular portion of murine interleukin 1 receptor types 1 and 2, is expressed in growth-stimulated BALB/c-3T3 cells in the presence of 50 micrograms/ml of cycloheximide. The treatment with 1,000 U/ml of purified native murine beta-interferon superinduced, rather than suppressed, the ST2 mRNA expression as in the cases of c-myc and JE mRNAs. These results suggested that the murine ST2 gene belongs to the family of primary response genes induced by growth factors. Furthermore, a longer ST2-related mRNA was found in BALB/c-3T3 cells that were stimulated to proliferate in the presence of cycloheximide.