The use of glucan as immunostimulant in the treatment of a severe case of chromoblastomycosis

作者：Conceição de Maria Pedrozo e Silva de Azevedo, Sirley Garcia Marques, Maria Aparecida de Resende, Azizedite Guedes Gonçalves, Daniel Vagner de Castro Lima Santos, Raimunda Ribeiro da Silva, Maria Glória Teixeira Sousa, Sandro Rogério de Almeida · 发表于：Mycoses · 年份：2008 · DOI：10.1111/j.1439-0507.2007.01485.x · 被引用次数：26 · 研究领域：Fungal Infections and Studies、Antifungal resistance and susceptibility、Infections and bacterial resistance

We report the case of an alternative treatment for a patient with a severe form of chromoblastomycosis that responded poorly to the traditional antifungal therapy. We hereby show, in this study, the improvement of lesions after treatment with itraconazole associated with an intramuscular administration of glucan. We observed that the regression of lesions was associated with an improvement of the cellular immune response. This favourable response that we observed suggests that the therapeutic regimen we used might be an option for the treatment of patients with a severe form of chromoblastomycosis.