Pharmacology of Systemic Antifungal Agents

作者：Elizabeth S. Dodds Ashley, Russell Edward Lewis, James S. Lewis, Craig A. Martin, David R. Andes · 发表于：Clinical Infectious Diseases · 年份：2006 · DOI：10.1086/504492 · 被引用次数：315 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Synthesis and Biological Evaluation

Traditionally, many invasive fungal infections were associated with a poor prognosis, because effective therapeutic options were limited. The recent development of new antifungal agents has significantly contributed to the successful treatment of fungal diseases. These drugs offer novel mechanisms of action and expanded spectrums of activity over traditional treatment options. However, with these new agents comes the need for increased awareness of the potential interactions and toxicities associated with these drugs. Therefore, an understanding of the pharmacokinetic and pharmacodynamic properties of the classes of antifungal compounds is vital for the effective management of invasive fungal infections. This review provides a summary of the pharmacologic principles involved in treatment of fungal diseases.