Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

作者：Andrea Cavalli, María Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti, Maurizio Recanatini, Carlo Melchiorre · 发表于：Journal of Medicinal Chemistry · 年份：2008 · DOI：10.1021/jm7009364 · 被引用次数：1142 · 研究领域：Cholinesterase and Neurodegenerative Diseases、Computational Drug Discovery Methods、Click Chemistry and Applications

A review. The authors review the investigations reported in the past decade that illustrate the ability of medicinal chemists to design multi-target-directed ligands (MTDLs) to confront neurodegenerative diseases. The authors briefly illustrate the multifactorial nature of these diseases before discussing the possible development of MTDLs in light of the known mol. bases of the main neurodegenerative pathologies.