Immunohistochemical and Biochemical Measurement of Estrogen and Progesterone Receptors in Primary Breast Cancer Correlation of Histopathology and Prognostic Factors

作者：M. Stierer, Harald Rosén, Renate Weber, Hanns Hanak, Jürgen Spona, Heinz Tüchler · 发表于：Annals of Surgery · 年份：1993 · DOI：10.1097/00000658-199307000-00004 · 被引用次数：144 · 研究领域：Breast Cancer Treatment Studies、Estrogen and related hormone effects、Breast Lesions and Carcinomas

Objective The authors investigated correlations of estrogen-receptor and progesterone-receptor with conventional risk factors as well as histopathology in patients with primary breast cancer. Summary Background Data Immunohistochemically determined hormone receptors have gained importance as prognosticators in primary breast cancer, but their definitive role has not yet been evaluated. Methods Tumor samples from 299 patients were examined for estrogen and progesterone receptors by biochemical and immunohistochemical assay. Correlations with established risk factors (tumor size, lymph node status, menopausal status, grading including subfactors) and histopathology were analyzed. Results The estrogen receptor, determined by immunohistochemical method revealed positivity in 80.6% of patients; biochemical measurement yielded 76.2% positive results. The progesterone receptor measured by immunohistochemistry yielded 61.3% positivity versus 55.8% detected by biochemical analysis. Invasive lobular, tubular, and ductal invasive carcinoma with prominent stroma content (“scirrhous carcinoma”) rather than ductal invasive carcinoma was more frequently estrogen-receptor positive with immunohistochemistry than with biochemical assay. For progesterone receptor, the same pattern of positivity was seen with immunohistochemical assay. With progesterone receptor determined biochemically, “scirrhous” and lobular carcinoma showed positive results in a lower proportion than invasive ductal and tubu...