NOX-free inflammasome activation

作者：Eicke Latz · 发表于：Blood · 年份：2010 · DOI：10.1182/blood-2010-06-287342 · 被引用次数：39 · 研究领域：Inflammasome and immune disorders、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Immune Response and Inflammation

In this issue of Blood, Meissner and colleagues discover that immune cells from CGD patients that have defective phagocyte oxidases show hyperactive inflammasome activation. These findings implicate that ROS down-regulate rather than enable caspase-1 activation and identify anti–IL-1 strategies as a potential therapy for the disproportionate inflammatory responses associated with CGD.