Dynamic Error Correction in Autocatalytic Peptide Networks

作者：Kay Severin, David H. Lee, José Antonio Martínez, Michael Vieth, M. Reza Ghadiri · 发表于：Angewandte Chemie International Edition · 年份：1998 · DOI：10.1002/(sici)1521-3773(19980202)37:1/2<126::aid-anie126>3.0.co;2-4 · 被引用次数：101 · 研究领域：Molecular spectroscopy and chirality、Photoreceptor and optogenetics research、Gene Regulatory Network Analysis

Make a mistake (produce a mutant peptide) and this simple nonlinear chemical network counteracts the error by upregulating the reproduction of the native sequence. The network reacts to these spontaneously occurring errors by subjugating the mutant peptides T9a and T26a for catalyzing the condensation of the peptide fragments E and N to produce the native replicator T. This mechanism of dynamic error correction could be of significance for the stabilization of genomic information.