Influence of Dietary Bile Salts on Blood Cholesterol Levels

作者：Leon Swell, Donald F. Flick, Henry Field, C. R. Treadwell · 发表于：Experimental Biology and Medicine · 年份：1953 · DOI：10.3181/00379727-84-20669 · 被引用次数：31 · 研究领域：Drug Transport and Resistance Mechanisms、Cholesterol and Lipid Metabolism、Peroxisome Proliferator-Activated Receptors

Different bile salts were fed to rats on high cholesterol-fat diets. The blood cholesterol increased very markedly with the feeding of sodium cholate and taurocholate, somewhat less with the feeding of desoxycholate and no increase was observed in those fed dehydrocholate. When sodium dehydrocholate, taurocholate, and dehydrocholate were fed successively to the same animal, taurocholate increased the blood cholesterol very markedly while dehydrocholate first had no effect and later lowered it. The results of this study agree in general with the findings of the preceding study on the in vitro effect of bile salts on cholesterol esterase activity, in that a comparable pattern of activity was observed in relation to the effect of bile salts on the blood cholesterol. It is suggested that the bile salts are necessary for cholesterol absorption because they are a necessary co-factor for cholesterol esterase activity.