Alterations in the Pulsatile Mode of Growth Hormone Release in Men and Women with Insulin-Dependent Diabetes Mellitus*

作者：Christopher M. Asplin, AMILTON C. S. FARIA, ELISABETH C. CARLSEN, Veronica A. Vaccaro, Richard E. Barr, Ali Iranmanesh, Mary Lee, Johannes D. Veldhuis, William S. Evans · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：1989 · DOI：10.1210/jcem-69-2-239 · 被引用次数：173 · 研究领域：Regulation of Appetite and Obesity、Growth Hormone and Insulin-like Growth Factors、Diabetes Management and Research

The mechanisms responsible for the elevated levels of circulating GH observed in diabetes mellitus (DM) remain incompletely defined. To assess the episodic fluctuations in serum GH as a reflection of hypothalamic-pituitary activity, we accumulated GH concentration-time series in a total of 48 adult men and women with and without insulin-dependent DM by obtaining serum samples at 10-min intervals over 24 h. Significant pulses of GH release were subsequently identified and characterized by an objective, statistically based pulse detection algorithm (Cluster) and fixed circadian (24-h) periodicities of secretory activity, resolved using Fourier expansion time-series analysis. Compared to those in age-matched controls, integrated 24-h concentrations of GH were 2- to 3.5-fold higher in diabetic men (P = 0.002) and women (P = 0.0005). Both men and women with DM had over 50% more GH pulses per 24 h than their non-DM counterparts. In addition, maximal GH pulse amplitude was markedly elevated in the men and women with DM (P = 0.0019 and 0.0189, respectively). That the increase in maximal pulse amplitude was accounted for by greater baseline levels was documented by a higher interpulse valley mean GH concentration in the diabetics compared to the controls (P = 0.0437 and 0.0056, men and women, respectively) and the absence of any difference in incremental pulse amplitude for either sex (P greater than 0.05). DM men had larger GH pulse areas (P = 0.039) than control men, apparently acco...