Resistance to Murine Tumors Conferred by Chronic Infection with Intracellular Protozoa, Toxoplasma gondii and Besnoitia jellisoni

作者：John B. Hibbs, Laurence Lambert, Jack S. Remington · 发表于：The Journal of Infectious Diseases · 年份：1971 · DOI：10.1093/infdis/124.6.587 · 被引用次数：182 · 研究领域：Toxoplasma gondii Research Studies、Herpesvirus Infections and Treatments、Cytomegalovirus and herpesvirus research

Toxoplasma gondii, a common latent intracellular parasite of man, has been shown to confer resistance against intracellular bacteria (e.g., Listeria) and virus (e.g., Mengo) in mice. Since this resistance is mediated by cells and persists for more than one year, it was pertinent to determine if Toxoplasma gondii and a related protozoan, Besnoitia jellisoni confer resistance against transplantable and autochthonus tumors. Significant resistance to development of mammary tumors was noted in C3H/He mice and to leukemia in AKR mice. Similar resistance was noted following challenge with Friend leukemia virus and sarcoma 180 in Swiss-Webster mice.