Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation

作者：Yoshinobu Kiso, Masahiro Tohkin, Hiroshi Hikino, Masao Hattori, Tatsuya Sakamoto, Tsuneo Namba · 发表于：Planta Medica · 年份：1984 · DOI：10.1055/s-2007-969714 · 被引用次数：221 · 研究领域：Pharmacological Effects of Natural Compounds、Phytochemistry and biological activity of medicinal plants、Chromatography in Natural Products

Glycyrrhizin and its analogues were screened for antihepatotoxic activity by in vitro assay methods using carbon tetrachloride (CCl 4 )-and galactosarnine-induced cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationship in these substances is discussed. The mechanism of inhibitory activity of glycyrrhizin and glycyrrhetinic acid in CCl 4 -produced liver damage was investigated by determining the effects of these substances on the initial steps in the sequence of events leading to liver lesion, revealing that anti-oxidative action plays an important part in the antihepatotoxic activity. 1 Liver-protective drugs, Part 14. Also Part 65 in the Tohoku University series on the validity of Oriental medicines.