High NK Cell Activity in Early Pregnancy Correlates with Subsequent Abortion with Normal Chromosomes in Women with Recurrent Abortion

作者：Hideto Yamada, Emi H. Kato, Yasuhiko Ebina, Shigeki Shimada, Mamoru Morikawa, Noriaki Sakuragi, Seiichiro Fujimoto, Gén Kobashi · 发表于：American Journal of Reproductive Immunology · 年份：2001 · DOI：10.1111/j.8755-8920.2001.460203.x · 被引用次数：107 · 研究领域：Reproductive System and Pregnancy、Immune Cell Function and Interaction、Ectopic Pregnancy Diagnosis and Management

PROBLEM: The aim of this study was to assess the role of natural killer (NK) cells in pregnant women with a history of recurrent spontaneous abortion (RSA). METHOD OF STUDY: Consecutive 66 pregnant women with a history of RSA were prospectively assessed for peripheral NK cell activity, percentage of the NK cell subsets, and subsequent pregnancy outcome. RESULTS: NK cell activity in women with subsequent live birth (group I) at 4-5 gestational weeks (GW) (mean +/- SD, 32.5 +/- 12.31%) significantly decreased at 6-7 GW (28.1 +/- 12.1%) and at 8 9 GW (28.0 +/- 11.8%). NK cell activity in women with subsequent abortion with normal chromosomes (group II) at 6 7 GW (41.2 +/- 19.0%) was significantly higher than that in group I women, while NK cell activity at 6-7 GW in women with subsequent abortion with abnormal chromosomes (group III) was the same as the level in group I women. CONCLUSIONS: High NK cell activity at 6-7 GW correlates with subsequent abortion with normal chromosomes.