Incidence and Risk Factors for Vertebral Fracture in Women and Men: 25-Year Follow-Up Results From the Population-Based Framingham Study

作者：Elizabeth J. Samelson, Marian T. Hannan, Yuqing Zhang, Harry K. Genant, David T. Felson, Douglas P. Kiel · 发表于：Journal of Bone and Mineral Research · 年份：2006 · DOI：10.1359/jbmr.060513 · 被引用次数：139 · 研究领域：Bone health and osteoporosis research、Spinal Fractures and Fixation Techniques、Hip and Femur Fractures

UNLABELLED: This study evaluates baseline characteristics of 704 women and men in the Framingham Study with respect to long-term risk of incident vertebral fracture. Incidence was 24% in women and 10% in men. Few factors in middle-aged persons, except prevalent (moderate) fracture and alcohol consumption (in men), predicted long-term incidence of vertebral fracture. INTRODUCTION: We studied potential risk factors in women and men in middle adult years to help identify individuals at increased long-term risk of vertebral fracture in advanced age. MATERIALS AND METHODS: Participants included Framingham cohort members who underwent radiographic examinations at baseline in 1967-1969 (mean age, 53 years) and follow-up in 1992-1993. Semiquantitative methods were used to determine incident fracture, defined as any vertebral body graded normal at baseline and at least mildly deformed (20-25% reduction or more in any vertebral height) at follow-up. Information on potential risk factors was obtained from examinations conducted at or before baseline radiography. RESULTS: Prevalence of vertebral fracture was similar (14%) in women and men, although incidence was greater in women (24%) than men (10%). Alcohol consumption increased fracture risk in men. Multivariable-adjusted ORs increased from 1.78 in men who consumed 1-3 oz of alcohol per week in middle-age years to 4.61 in those with intakes of > or =4 oz/week (trend, P = 0.0099). Age, height, weight, grip strength, physical activity, m...