Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

作者：Jonas Nilsson, Johan Skog, Annika Nordstrand, Vladimir Baranov, Lucia Mincheva‐Nilsson, Xandra O. Breakefield, Anders Widmark · 发表于：British Journal of Cancer · 年份：2009 · DOI：10.1038/sj.bjc.6605058 · 被引用次数：786 · 研究领域：Extracellular vesicles in disease、Prostate Cancer Treatment and Research、Cancer-related molecular mechanisms research

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.