Association of Serum Adiponectin Levels with Artherosclerosis and the Metabolic Syndrome in Obese Children

作者：Yunling Liu, Hong-Ri Liang, Hao-Tian Liu, Shuying Li, Zhou Ye-ying, Hui-Ling Cheng, Liaosheng Zhou · 发表于：Journal of Pediatric Endocrinology and Metabolism · 年份：2010 · DOI：10.1515/jpem.2010.122 · 被引用次数：18 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Cardiovascular Disease and Adiposity、Biomarkers in Disease Mechanisms

BACKGROUND: The atherosclerotic process starts at an early age and is linked to obesity. However, the exact pathophysiological mechanism is poorly understood. OBJECTIVE: To investigate the relationship between serum adiponectin and metabolic syndrome and early arteriosclerosis. SUBJECTS: 176 obese and 88 normal children. METHODS: Ultrasound measurement was performed to investigate IMT, FMD, carotid artery compliance (CAC). Adiponectin was measured by enzyme-linked immunosorbent assay. RESULTS: Adiponectin levels correlated negatively with obese markers, blood pressure, fasting insulin, high sensitive CRP, HOMA-IR and IMT; marginally positively associated with CAC and HDL-c. The risk of metabolic syndrome increased 3.43 times when adiponectin levels were less than 7060 ng/ml. Heavy obesity, hypertension, low HDL-c, fasting hyperinsulin, High LDL-c and metabolic syndrome percentage were different in three groups according to the cut-off value of adiponectin. CONCLUSIONS: Low adiponectin levels are associated with a high incidence of metabolic syndrome.