Effect of Calcitonin on the Rates of Bone Formation and Resorption in the Rat

作者：David J. Baylink, E. R. Morey, Charles L. Rich · 发表于：Endocrinology · 年份：1969 · DOI：10.1210/endo-84-2-261 · 被引用次数：72 · 研究领域：Bone Metabolism and Diseases、Bone health and osteoporosis research

The rates of matrix and bone formation and bone resorption were measured histologically in the tibial diaphysis of thyroparathyroidectomized rats. Compared to control animals, the rates of matrix and bone formation and bone resorption both were decreased significantly in rats given 3 Hirsch units of calcitonin every 8 hr for 6 days. The magnitude of the decrease of resorption was 68%, that of bone formation was 24%, and that of matrix formation was 22%. (Endocrinology 84: 261, 1969)