Electrospinning of Nanofiber Fibrinogen Structures

作者：Gary E. Wnek, Marcus E. Carr, David G. Simpson, Gary L. Bowlin · 发表于：Nano Letters · 年份：2002 · DOI：10.1021/nl025866c · 被引用次数：555 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Tissue Engineering and Regenerative Medicine、Mesenchymal stem cell research

The first results of electrospinning fibrinogen nanofibers for use as a tissue-engineering scaffold, wound dressing, or hemostatic bandage are reported. Structures composed of fibrinogen fibers with an average diameter of 80−700 nm were electrospun from solutions composed of human or bovine fibrinogen fraction I dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol and minimal essential medium (Earle's salts). In summary, the electrospinning process is a simple and efficient technique for the fabrication of 3D structures composed of fibrinogen fibers, as would be present in the physiologic environment.