Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs

作者：Michael Kaplan, James W. Hinds · 发表于：Science · 年份：1977 · DOI：10.1126/science.887941 · 被引用次数：1465 · 研究领域：Neurogenesis and neuroplasticity mechanisms、Axon Guidance and Neuronal Signaling、Neuroscience and Neuropharmacology Research

Three-month-old rats were injected intraperitoneally with [3H]thymidine (4.3 microcuries per gram of body weight) and allowed to survive for 30 days. Radioautography of 1-micrometer sections revealed labeled cells in the granular layers of dentate gyrus and olfactory bulb; these were confirmed as neurons by electron microscopy of reembedded 1-micrometer sections.