Rat brains also have a default mode network

作者：Hanbing Lu, Qihong Zou, Hong Mei Gu, Marcus E. Raichle, Elliot A. Stein, Yihong Yang · 发表于：Proceedings of the National Academy of Sciences · 年份：2012 · DOI：10.1073/pnas.1200506109 · 被引用次数：638 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Memory and Neural Mechanisms

The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.