Cellular Mechanisms for Lipid Deposition in Atherosclerosis

作者：Howard L. Bleich, Emily S. Boro, DONALD M. SMALL · 发表于：New England Journal of Medicine · 年份：1977 · DOI：10.1056/nejm197710202971608 · 被引用次数：155 · 研究领域：Antioxidant Activity and Oxidative Stress、Fatty Acid Research and Health、Cholesterol and Lipid Metabolism

(First of Two Parts*)RECENT research on the pathogenesis of atherosclerosis has focused on the physicochemical nature of the arterial wall and on the roles of smooth-muscle cells, serum lipoproteins and defects in cellular metabolism of cholesterol that lead to early atherosclerosis. Smooth-muscle-cell proliferation is widely believed to be the initial cellular event in the pathogenesis of atherosclerosis.1 A stimulus, such as an injury, a chemical or a virus, is thought to cause smooth-muscle cells to migrate into the intima, where they may transform, proliferate, produce connective tissue and lipid and thus initiate the early lesion. Cellular isoenzyme typing . . .