Diffusion Tensor Imaging of Commissural and Projection White Matter in Tuberous Sclerosis Complex and Correlation with Tuber Load

作者：Gustavo Novelino Simão, Charles Raybaud, Sylvester H. Chuang, Cristina Go, O. Carter Snead, Elysa Widjaja · 发表于：American Journal of Neuroradiology · 年份：2010 · DOI：10.3174/ajnr.a2033 · 被引用次数：45 · 研究领域：Tuberous Sclerosis Complex Research、Neurofibromatosis and Schwannoma Cases、Epilepsy research and treatment

BACKGROUND AND PURPOSE: Cortical and white matter changes have been identified outside the MR imaging-visible cortical/subcortical tubers in the tuberous sclerosis complex. The aim of this study was to evaluate DTI changes in the corpus callosum and internal capsules and to correlate the DTI changes with cortical/subcortical tuber load. MATERIALS AND METHODS: Twelve TSC patients and 23 controls underwent MR imaging including DTI. FA, trace, D( ||), and D() of genu and splenium of corpus callosum and right and left internal capsules were assessed. The number and volume of cortical/subcortical tubers were correlated with DTI indices of corpus callosum and internal capsules. RESULTS: In the genu and splenium, FA was lower and trace (P < .01) and D() were higher (P < .01), and in the internal capsules, trace was higher (P = .04) in TSC patients compared with controls. The total tuber volume correlated positively with trace of genu (r = 0.77, P < .01) and splenium (r = 0.69, P = .01) and with D() of splenium (r = 0.68, P = .01), and negatively with FA of splenium (r = -0.60, P = .04) of corpus callosum. The left and right hemispheric tuber volume correlated positively with trace of left (r = 0.56, P = .05) and right (r = 0.67, P = .02) internal capsules. CONCLUSIONS: Our findings of reduced FA, elevated trace, and elevated D() in the corpus callosum and internal capsules may be related to abnormalities in myelin. The correlations between tuber volume and DTI indices in corpus call...