Sequence homology between two membrane transport ATPases, the Kdp-ATPase of Escherichia coli and the Ca2+-ATPase of sarcoplasmic reticulum.

作者：Joanne E. Hesse, Lothar Wieczorek, Karlheinz Altendorf, Alise S. Reicin, Elizabeth Dorus, Wolfgang Epstein · 发表于：Proceedings of the National Academy of Sciences · 年份：1984 · DOI：10.1073/pnas.81.15.4746 · 被引用次数：209 · 研究领域：RNA and protein synthesis mechanisms、Bacterial Genetics and Biotechnology、Machine Learning in Bioinformatics

We have determined the DNA sequences of the genes encoding the three structural proteins of the Kdp-ATPase, an ATP-driven potassium transport system of Escherichia coli. Regions of the predicted amino acid sequence of KdpB, the phosphorylated protein of the system, are homologous to regions of the Ca2+-ATPase of rabbit sarcoplasmic reticulum. The phosphorylated aspartate residue of the latter is within a region of homology.