Emergence in Italy of Klebsiella pneumoniae Sequence Type 258 Producing KPC-3 Carbapenemase

作者：Tommaso Giani, Marco Maria D’Andrea, Patrizia Pecile, Luisa Borgianni, Pierluigi Nicoletti, Francesco Tonelli, Alessandro Bartoloni, Gian María Rossolini · 发表于：Journal of Clinical Microbiology · 年份：2009 · DOI：10.1128/jcm.01773-09 · 被引用次数：127 · 研究领域：Antibiotic Resistance in Bacteria、Urinary Tract Infections Management、Tuberculosis Research and Epidemiology

KPC-type carbapenemases are emerging resistance determinants in Klebsiella pneumoniae and other gram-negative pathogens, being an increasingly important mechanism of acquired resistance to carbapenems and other β-lactams (9, 10). KPC producers have recently undergone an important dissemination in the United States, Israel, and Greece and have been sporadically detected elsewhere in Europe, Latin America, and Asia (see references 1, 5, and 9 and references therein). Population analyses of KPC-producing K. pneumoniae isolates by multilocus sequence typing (MLST) have revealed the successful international spread of a sequence type (ST) 258 clone (1, 7, 12).