Water-Promoted Synthesis of Enaminones: Mechanism Investigation and Application in Multicomponent Reactions

作者：Yunyun Liu, Rihui Zhou, Jie‐Ping Wan · 发表于：Synthetic Communications · 年份：2013 · DOI：10.1080/00397911.2012.715712 · 被引用次数：59 · 研究领域：Multicomponent Synthesis of Heterocycles、Synthesis and Characterization of Pyrroles、Synthesis of heterocyclic compounds

Highly stereoselective synthesis of Z-enaminones bearing reactive secondary amino group has been successfully performed in water using tertiary amino group functionalized enaminones under ambient conditions. An interesting promotion effect of water on the reaction via hydrolysis–dehydration condensation has been observed through a designed isotope labeling experiment. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.