Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.

作者：James W. Prichard, Douglas L. Rothman, Edward J. Novotny, Ognen A. C. Petroff, Takashi Kuwabara, Malcolm J. Avison, A. Howseman, Christopher C. Hanstock, Robert G. Shulman · 发表于：Proceedings of the National Academy of Sciences · 年份：1991 · DOI：10.1073/pnas.88.13.5829 · 被引用次数：615 · 研究领域：Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies、Neural dynamics and brain function

Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.