Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

作者：Harparkash Kaur, Barry B. Halliwell · 发表于：FEBS Letters · 年份：1994 · DOI：10.1016/0014-5793(94)00722-5 · 被引用次数：709 · 研究领域：Nitric Oxide and Endothelin Effects、Electron Spin Resonance Studies、Traditional Chinese Medicine Analysis

Reaction of nitric oxide (NO.) with superoxide radical generates peroxy-nitrite, which can decompose to products that nitrate aromatic amino acids. Such nitro-aromatics may be 'markers' of NO.-dependent oxidative damage. Blood serum and synovial fluid from patients with the inflammatory joint disease rheumatoid arthritis contain 3-nitrotyrosine. By contrast, body fluids from normal subjects and patients with osteoarthritis contain no detectable 3-nitrotyrosine; much lower levels were found in serum from patients in the early stages of rheumatoid arthritis. This is evidence that NO. plays a role in joint damage in rheumatoid arthritis.