The Methylation Effect in Medicinal Chemistry

作者：Eliezer J. Barreiro, Arthur Eugen Kümmerle, Carlos Alberto Manssour Fraga · 发表于：Chemical Reviews · 年份：2011 · DOI：10.1021/cr200060g · 被引用次数：1020 · 研究领域：HIV/AIDS drug development and treatment、Chemical Reaction Mechanisms、Pharmaceutical studies and practices

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTThe Methylation Effect in Medicinal ChemistryEliezer J. Barreiro*†‡§, Arthur E. Kümmerle†§, and Carlos A. M. Fraga†‡§View Author Information† Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil‡ Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil§ Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, BrazilPhone: 55-21-25626644. E-mail: [email protected]. Website: http://www.farmacia.ufrj.br/lassbio.Cite this: Chem. Rev. 2011, 111, 9, 5215–5246Publication Date (Web):June 1, 2011Publication History Received18 February 2011Published online1 June 2011Published inissue 14 September 2011https://pubs.acs.org/doi/10.1021/cr200060ghttps://doi.org/10.1021/cr200060greview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views18979Altmetric-Citations659LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up ...